Novel Heterocyclic Systems: Synthetic Approaches, Reactivity and Biological Activities

    Le Doyen de la Faculté des Sciences et Techniques de Béni Mellal porte à la connaissance du public que Monsieur ER-RAQIOUI Redouane, soutiendra une thèse de Doctorat intitulée : «Novel Heterocyclic Systems: Synthetic Approaches, Reactivity and Biological Activities».

    La soutenance publique aura lieu Mardi 28 Avril 2026 à 10h00 à l’Amphi de Conférences, à la Faculté des Sciences et Techniques de Béni Mellal, devant le jury composé de :

• Monsieur Abderrafia HAFID : Professeur, Faculté des Sciences et Techniques, Université Sultan Moulay Slimane, Béni Mellal, Président ;

• Monsieur Abdellah Hannioui : Professeur, Faculté des Sciences et Techniques, Université Sultan Moulay Slimane, Béni Mellal, Rapporteur ;

• Madame Najat ABBASSI : Maître de Conférences Habilité, Faculté des Sciences, Université Ibnou Zohr, Agadir, Rapporteure ;

• Monsieur Amine MOUBARIK : Professeur, Faculté Polydisciplinaire, Université Sultan Moulay Slimane, Béni Mellal, Rapporteur ;

• Madame Maria da Graça de Pinho Morgado Silva Neves : Professeure, Université Aveiro, Aveiro, Portugal, Examinatrice ;

• Madame Maria do Amparo Ferreira Faustino : Professeure, Université Aveiro, Aveiro, Portugal, Examinatrice ;

• Monsieur Nuno Miguel Malavado Moura : Maître de Conférences Habilité, Université Aveiro, Aveiro, Portugal, Examinatrice ;

• Monsieur Said ABOURICHA : Professeur, Faculté Polydisciplinaire, Université Sultan Moulay    Slimane, Béni Mellal, Examinateur ;

• Monsieur El Mostapha RAKIB : Professeur, Ecole Supérieure de Technologie, Université Sultan Moulay Slimane, Fkih Ben Salah, Directeur de thèse ;

Abstract: 

    Heterocyclic compounds play a central role in medicinal chemistry, especially in the search for new antimicrobial and anticancer agents.  

    Chapter 1, provides an overview indazole and rhodanine scaffolds, highlighting their biological relevance. Indazole derivatives are known for their antimicrobial and anticancer properties, while rhodanine derivatives also show significant potential against infections and tumors. This chapter, introduces some synthetic methods used to prepare and modify these compounds. These studies demonstrate that indazole and rhodanine are promising building blocks for the development of new therapeutic molecules 

    Chapter 2 describes the synthesis of six new indazole–benzimidazole hybrid compounds and the evaluation of their antimicrobial activity. The results showed significant biological activity, and molecular modeling studies provided insights into  the structure–activity relationship. 

    Chapter 3 focuses on the synthesis of spiro derivatives of N-allyl rhodanine via 1,3-dipolar cycloaddition reactions. Some of these compounds showed promising antiproliferative activity against cancer cell lines.

    Chapter 4 investigates the reactivity of benzimidazo-thiazolone derivatives with 1,3-dipoles.  The reaction outcomes showed that the products obtained depend on the nature of the starting scaffold, the 1,3-dipole, and the reaction conditions. Theoretical studies helped rationalize these outcomes through proposed mechanisms. 

     Overall, this work highlights the importance of indazole and rhodanine derivatives in the development of new heterocyclic compounds with significant antimicrobial and anticancer potential. It also reveals divergent 1,3-dipolar reactivity in selected scaffolds, including benzimidazo-thiazolone derivatives, which depends on the scaffold, dipole, and reaction conditions.

Keywords: Indazole; Rhodanine; 1,3-Dipolar Cycloaddition; Hybrid Compounds; Antimicrobial Activity; Anticancer Activity; Molecular Modeling.